City
and County of San Francisco
Edwin
M. Lee
Mayor
|
San
Francisco Department of Public Health
Barbara
A. Garcia, MPA
Director
of Health
|
Embargoed until 5p.m. Eastern Time
|
Eileen Shields, Public Information Officer
|
December 31, 2012
|
415/554-2507 (o) 415/370-3377 (cell)
|
Study
Shows Naloxone Cost-Effective in Preventing
Overdose Deaths
San Francisco, CA, January 1, 2013 - The Annals of
Internal Medicine released a study this week demonstrating that giving
heroin users the overdose antidote naloxone is a cost-effective way to prevent
overdose death and save lives. Phillip Coffin, MD, Director of Substance Use Research
at the San Francisco Department of Public Health and Assistant Clinical Professor
at the University of California San Francisco, and Sean Sullivan, PhD,
Professor and Director of the Pharmaceutical Outcomes Research and Policy
Program at the University of Washington, co-authored the study.
Drug overdose is now the
leading cause of injury death in the United States with opioids, such as heroin,
accounting for about 80% of those deaths. Naloxone is a safe and effective
antidote that works by temporarily blocking opioid receptors. As of 2010, 183
public health programs around the country, including those supported by the San
Francisco Department of Public Health, had trained over 53,000 individuals in
how to use naloxone. These programs had documented more than 10,000 cases of
successful overdose reversals.
The authors of this study
developed a mathematical model to estimate the impact of distributing naloxone
in this way. Their model was based on conservative estimates of the number of
overdoses that occur each year. It accounted for people who overdose
repeatedly, and it acknowledged that most people who overdose will survive
whether or not they get naloxone.
In their basic model, Coffin
and Sullivan estimated that reaching 20% of a million heroin users with
naloxone would prevent about 9,000 overdose deaths over their lifetime. One
life would be saved for every 164 naloxone kits given out. Based on optimistic
assumptions, naloxone could prevent as many as 43,000 deaths – one life for
every 36 kits given out.
Naloxone distribution would
cost about $400 for every quality-adjusted year of life gained. This value is
well below the customary $50,000 cutoff for medical interventions. It is also
cheaper than most well-accepted prevention programs in medicine – most similar
to the cost-effectiveness of smoking cessation or checking blood pressure. All
reasonable assumptions produced costs that were well within traditional
guidelines for cost-effectiveness.
“Naloxone is a highly cost-effective way
to prevent overdose deaths,” said Dr Coffin. “And, as a researcher at the
Department of Public Health, my priority is maximizing our resources to help
improve the health of the community.”
Naloxone distribution has existed in San
Francisco since the late 1990s, with SFDPH support since 2004. During that
time, heroin overdose fatalities slowly decreased from a peak of 155 in 1995 to
10 in 2010. Opioid analgesic deaths (e.g., oxycodone, methadone, or
hydrocodone) remain elevated, with 121 deaths in 2010. Efforts are currently
underway to expand access to this lifesaving medication for patients receiving
prescription opioids as well.
Contact Information and Follow-up
To obtain a copy of this study, see Annals of Internal Medicine
To discuss the paper, contact Dr. Coffin, pcoffin@gmail.com
###
A press release is a short document consisting of only three or four paragraphs. In total you should try to keep a grand opening press release sample about 500 words, which is the typical size of a page.
ReplyDelete