15 papers this month.
Dodington
J, Violano P, Baum CR, Bechtel K.
Pediatr Res. 2016 Sep 27.
doi: 10.1038/pr.2016.193. [Epub ahead of print] Review.
Comment: Review
of safety efforts in public health.
Behar E,
Rowe C, Santos GM, Murphy S, Coffin PO.
Ann Fam Med. 2016
Sep;14(5):431-6. doi: 10.1370/afm.1972.
Comment: This
is a partner paper to the study
results reported a couple of months ago. Mixed methods interviews with 60
randomly selected patients on longterm opioid therapy for chronic pain who had
been prescribed naloxone. The co-prescribing effort reached a population that
was not really accessing naloxone through other community distribution sites in
San Francisco. Some reported improved safety with opioids since receiving
naloxone and none reported more high-risk use behaviors. About half of those
who had overdosed denied “overdose” and described it as a bad reaction.
Dunn KE,
Barrett FS, Yepez-Laubach C, Meyer AC, Hruska BJ, Petrush K, Berman S, Sigmon
SC, Fingerhood M, Bigelow GE.
J Subst Abuse Treat. 2016
Dec;71:1-7.
Comment: Can’t
access the paper, but the abstract suggests higher rates of overdose among
rural drug users versus urban, while there were fewer overdose risk behaviors
among rural users (potentially raising concerns about our risk behaviors, which
were retrospectively developed).
Scott N,
Carrotte ER, Higgs P, Cogger S, Stoové MA, Aitken CK, Dietze PM.
Drug Alcohol Depend. 2016 Sep 11;168:140-146. doi:
10.1016/j.drugalcdep.2016.08.638. [Epub ahead of print]
Comment: People
who inject drugs have more psychological distress than the general population.
Not surprised that intentional overdose (i.e. suicide attempt) is associated
with psychological distress.
Klar SA,
Brodkin E, Gibson E, Padhi S, Predy C, Green C, Lee V.
MMWR Morb Mortal Wkly Rep.
2016 Sep 23;65(37):1015-1016. doi: 10.15585/mmwr.mm6537a6.
Comment: Fentanyl
in crack. Ugh.
Ottawa (ON): Canadian
Agency for Drugs and Technologies in Health; 2016 Sep 02.
Comment: Buprenorphine
is safe, effective, and cost-effective compared to methadone.
Dunn KE,
Barrett FS, Fingerhood M, Bigelow GE.
Pain Med. 2016 Sep 20.
pii: pnw228. [Epub ahead of print]
Comment: Not
enough of these type of studies – addressing opioid overdose experience and
knowledge among patients on opioids for chronic pain. 19% had a lifetime
history of opioid overdose – similar to the study #2 above, although that study
found that number to double when patients were asked about “bad reactions” that
were characterized by not breathing or not being able to be woken up without
help after using opioids.
Davis CS,
Burris S, Beletsky L, Binswanger I.
Subst Abus. 2016 Sep 20:0.
[Epub ahead of print]
Comment: There
is no particular liability in prescribing naloxone.
El Burai
Félix S, Mack KA, Jones CM.
P R Health Sci J. 2016
Sep;35(3):165-9.
Comment: Interesting
that overdose deaths aren’t increasing as Rx opioid distribution is increasing.
Hmm.
Berlin J.
Tex Med. 2016 Sep
1;112(9):49-54.
Comment: Standing
orders for naloxone in Texas.
Fife A,
Postier A, Flood A, Friedrichsdorf SJ.
J Opioid Manag. 2016
May-Jun;12(2):123-30. doi: 10.5055/jom.2016.0324.
Comment:
When we convert people from one opioid to another we use conversion ratios.
When converting to methadone, kids were very under-dosed.
Easterling
KW, Mack KA, Jones CM.
J Safety Res. 2016
Sep;58:105-9. doi: 10.1016/j.jsr.2016.07.004. Epub 2016 Aug 7.
Comment: Most
overdose deaths occur at home, more so for prescription opioid deaths.
McAuley
A, Bouttell J, Barnsdale L, Mackay D, Lewsey J, Hunter C, Robinson M.
Addiction. 2016 Sep 10.
doi: 10.1111/add.13602. [Epub ahead of print]
Comment: Naloxone
distribution was not associated with a reduction in ambulances attending opioid
overdoses. There could be other explanations for this, but the authors believe
it suggests that people call for emergency medical assistance just as often
when naloxone is available as when it is not.
Elzey MJ,
Fudin J, Edwards ES.
Expert Opin Drug Deliv. 2016 Sep 16:1-14. [Epub
ahead of print]
Comment: Hmm ... an unambiguous endorsement - that nothing but the auto-injector should be used - coming from the makers of the auto-injector.
Mohr AL,
Friscia M, Papsun D, Kacinko SL, Buzby D, Logan BK.
J Anal Toxicol. 2016 Sep
1. [Epub ahead of print]
Comment: Synthetic
opioids. Harrumph.
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