Sunday, March 8, 2015

PubMed Update November 2014 - February 2015

Catching up on 51 papers in 4 months. Did you miss me?

Rech MA, Donahey E, Cappiello Dziedzic JM, Oh L, Greenhalgh E.
Pharmacotherapy. 2014 Dec 4. doi: 10.1002/phar.1522. [Epub ahead of print]
Comment: Review of management of drug toxicities among novel, synthetic compounds.

Ray B, O'Donnell D, Kahre K.
Drug Alcohol Depend. 2015 Jan 1;146:107-10. doi: 10.1016/j.drugalcdep.2014.10.026. Epub 2014 Nov 8.
Comment: Police officers like being trained to carry naloxone.

Robinson A, Wermeling DP.
Am J Health Syst Pharm. 2014 Dec 15;71(24):2129-35. doi: 10.2146/ajhp130798.
Comment: Review of intranasal naloxone for overdose reversal.

Dasgupta N, Creppage K, Austin A, Ringwalt C, Sanford C, Proescholdbell SK.
Drug Alcohol Depend. 2014 Dec 1;145:238-41. doi: 10.1016/j.drugalcdep.2014.10.005. Epub 2014 Oct 18.
Comment: Heroin overdoses are increasing.

Jones JD, Roux P, Stancliff S, Matthews W, Comer SD.
Int J Drug Policy. 2014 Jan;25(1):166-70. doi: 10.1016/j.drugpo.2013.05.006. Epub 2013 Jun 15.
Comment: Brief overdose training works for naloxone distribution. This is important because many places are requiring prolonged trainings that end up limiting access to those who are unable or unwilling to invest that degree of time.

Behar E, Santos GM, Wheeler E, Rowe C, Coffin PO.
Drug Alcohol Depend. 2015 Mar 1;148:209-12. doi: 10.1016/j.drugalcdep.2014.12.009. Epub 2014 Dec 19.
Comment: Again, brief overdose training works for naloxone distribution.

Coffin PO, Rowe C, Santos GM.
Curr HIV/AIDS Rep. 2015 Jan 15. [Epub ahead of print]
Comment: Review of interventions for PWIDs in 2013 and 2014, including naloxone.

Potier C, Laprévote V, Dubois-Arber F, Cottencin O, Rolland B.
Drug Alcohol Depend. 2014 Dec 1;145C:48-68. doi: 10.1016/j.drugalcdep.2014.10.012. Epub 2014 Oct 23. Review.
Comment: The attract the most marginalized drug users, promote safer injection, enhance primary care access, reduce overdose frequency, reduce public injecting and improper syringe disposal. They don’t increase drug injecting, drug trafficking or crime.

Haegerich TM, Paulozzi LJ, Manns BJ, Jones CM.
Drug Alcohol Depend. 2014 Dec 1;145C:34-47. doi: 10.1016/j.drugalcdep.2014.10.001. Epub 2014 Oct 14. Review.
Comment: We don’t know anything

Latypov A, Otiashvili D, Zule W.
Int J Drug Policy. 2014 Oct 7;25(6):1204-1214. doi: 10.1016/j.drugpo.2014.09.011. [Epub ahead of print]
Comment: Takikistan has a dire need for vast expansion in agonist maintenance and naloxone services.

Harris M, Forseth K, Rhodes T.
Int J Drug Policy. 2015 Jan;26(1):51-8. doi: 10.1016/j.drugpo.2014.09.009. Epub 2014 Sep 28.
Comment: A discussion of the downsides of a heroin drought and how drug users cope.

Arribas-Ibar E, Sánchez-Niubò A, Majó X, Domingo-Salvany A, Brugal MT.
Harm Reduct J. 2014 Nov 22;11(1):33. doi: 10.1186/1477-7517-11-33.
Comment: I’m not entirely clear that these programs involve naloxone distribution, but it looks like they do with a 1-hour training. When they recruited from sites with programs, 43.5% of drug users had participated.

Garimella T, Wang R, Luo WL, Wastall P, Kandoussi H, Demicco M, Bruce D, Hwang C, Bertz R, Bifano M.
J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19628. doi: 10.7448/IAS.17.4.19628. eCollection 2014.
Comment: Another hepatitis C medication being tested for use in people on opioid agonist maintenance treatment. No meaningful interaction.

Joseph D, Schobelock MJ, Riesenberg RR, Vince BD, Webster LR, Adeniji A, Elgadi M, Huang F.
Antimicrob Agents Chemother. 2015 Jan;59(1):498-504. doi: 10.1128/AAC.04046-14. Epub 2014 Nov 10.
Comment: Another hepatitis C medication being tested for use in people on opioid agonist maintenance treatment. No meaningful interaction.

Strang J, Bird SM, Dietze P, Gerra G, McLellan AT.
BMJ. 2014 Nov 4;349:g6580. doi: 10.1136/bmj.g6580. No abstract available.
Comment: England seems to be creeping forward with naloxone even in the absence of final data from large randomized trials.

Johnson B, Richert T.
J Psychoactive Drugs. 2014 Nov-Dec;46(5):427-35. doi: 10.1080/02791072.2014.960109.
Comment: This is an interesting issue. Agonist agents are often in short supply and can help people in withdrawal, who want to self-detox, etc. As the authors write: “Patients who share their medication with opioid-dependent friends are seen as less culpable than those who sell to anyone for money.”

Bailey AM, Wermeling DP.
Ann Pharmacother. 2014 May;48(5):601-6. doi: 10.1177/1060028014523730. Epub 2014 Feb 12.
Comment: Pharmacists and naloxone!

Origer A, Lopes da Costa S, Baumann M.
Eur Addict Res. 2014;20(2):87-93. doi: 10.1159/000355170. Epub 2013 Oct 31.
Comment: Interesting look at male versus female decedents. While men were more likely to die, women were more likely to die earlier in their drug use career and to use other psychoactive prescription medicaitons.

Lee WK, Ti L, Hayashi K, Kaplan K, Suwannawong P, Wood E, Kerr T.
Subst Abuse Treat Prev Policy. 2013 Sep 10;8:32. doi: 10.1186/1747-597X-8-32.
Comment: This study found no association between needing assistance with injection and non-fatal overdose. The data on this has been mixed, with some studies finding an association and some finding no association. As women are more likely to get assistance with injection and men are more likely to overdose, I wonder if the effect may wash out and more gender-specific analyses may make sense.

Heimer R, Barbour R, Palacios WR, Nichols LG, Grau LE.
AIDS Behav. 2014 Mar;18(3):452-63. doi: 10.1007/s10461-013-0572-3.
Comment: Interesting use of geocoding by mapping overdose deaths on top of the sample for the study. Frequent overdoses and poor knowledge about overdose in rural CT. Important work.

Rosen K, Gutierrez A, Haller D, Potter JS.
Clin J Pain. 2014 Apr;30(4):295-300. doi: 10.1097/AJP.0b013e318298ddad.
Comment: Interesting survey of American Pain Society members showing that buprenorphine is indeed being used to treat chronic pain and is viewed as safer due to partial agonist activity (and reduced overdose risk).

Skeie I, Brekke M, Clausen T, Gossop M, Lindbaek M, Reinertsen E, Thoresen M, Waal H.
Eur Addict Res. 2013;19(4):194-201. doi: 10.1159/000345229. Epub 2012 Dec 21.
Comment: As has been well-documented in the past, terminating opioid agonist maintenance therapy has a heighted risk of overdose.

Bretteville-Jensen AL, Lillehagen M, Gjersing L, Andreas JB.
Drug Alcohol Depend. 2014 Dec 13. pii: S0376-8716(14)01981-4. doi: 10.1016/j.drugalcdep.2014.12.002. [Epub ahead of print]
Comment: Interesting assessment of overdose risk among those who use diverted substitution medications. The only associated with overdose was infrequent buprenorphine use. As using buprenorphine requires one to detox beforehand, and detox is associated with overdose, I wonder if this is picking up people who are really trying to cut back their use and thus increasing overdose risks.

Corrigan F, Wu Y, Tuke J, Coller JK, Rice KC, Diener KR, Hayball JD, Watkins LR, Somogyi AA, Hutchinson MR.
Brain Behav Immun. 2014 Dec 24. pii: S0889-1591(14)00608-4. doi: 10.1016/j.bbi.2014.12.019. [Epub ahead of print]
Comment: Morphine and alcohol appear to interact in surprising ways neurochemically, perhaps accounting for heightened overdose risk.

Beaudoin FL, Merchant RC, Janicki A, McKaig DM, Babu KM.
Ann Emerg Med. 2014 Dec 17. pii: S0196-0644(14)01514-5. doi: 10.1016/j.annemergmed.2014.11.016. [Epub ahead of print]
Comment: The majority of events were due to medication error.

Bazazi AR, Zelenev A, Fu JJ, Yee I, Kamarulzaman A, Altice FL.
Int J Drug Policy. 2014 Dec 2. pii: S0955-3959(14)00334-X. doi: 10.1016/j.drugpo.2014.11.010. [Epub ahead of print]
Comment: Amazing to have this work out of Malaysia. Shows more or less standard rates of overdose that have been documented in multiple other settings.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jun 20.
Comment: There are no data comparing lay naloxone to healthcare professional administered naloxone.

Zamani N, Hassanian-Moghaddam H, Hossein Bayat A, Haghparast A, Shadnia S, Rahimi M, Demaneh BH.
Toxicol Lett. 2014 Dec 12. pii: S0378-4274(14)01514-8. doi: 10.1016/j.toxlet.2014.12.007. [Epub ahead of print]
Comment: “Buprenorphine recovers opioid-overdose in morphine-dependent rats and bypasses the withdrawal-syndrome due to administration of naloxone.”

Fogger S, McGuinness TM.
J Psychosoc Nurs Ment Health Serv. 2015 Feb 1;53(2):27-30. doi: 10.3928/02793695-20150106-01.
Comment: A review of substituting prescription opioids with heroin due to cost of the former, and using opioid substitution therapy.

Wermeling DP.
Ther Adv Drug Saf. 2015 Feb;6(1):20-31. doi: 10.1177/2042098614564776. Review.
Comment: As the title says.

Nielsen MK, Johansen SS, Linnet K.
Forensic Sci Int. 2015 Mar;248:134-9. doi: 10.1016/j.forsciint.2015.01.004. Epub 2015 Jan 12.
Comment: Interesting work. No evidence of decreased exposure to methadone (so reduced tolerance of methadone unlikely a factor here). Evidence of multiple other depressant agents, including frequent heroin exposure.

Teesson M, Marel C, Darke S, Ross J, Slade T, Burns L, Lynskey M, Memedovic S, White J, Mills KL.
Addiction. 2015 Jan 23. doi: 10.1111/add.12860. [Epub ahead of print]
Comment: Really useful data here. After 11 years, 10.2% of the population had died and 24.8% were still using heroin; 46.6% were in current substance use disorder treatment. Major depression was a driver of poor outcomes.

Ray WA, Chung CP, Murray KT, Cooper WO, Hall K, Stein CM.
JAMA Intern Med. 2015 Mar 1;175(3):420-427. doi: 10.1001/jamainternmed.2014.6294.
Comment: Methadone was more risky than other opioids, even at low doses (<20mg per day). Still, it’s not possible to tease out all of the differences, such as why methadone was prescribed to one person and morphine to another.

Kolodny A, Courtwright DT, Hwang CS, Kreiner P, Eadie JL, Clark TW, Alexander GC.
Annu Rev Public Health. 2015 Jan 12. [Epub ahead of print]
Comment: A review of prescription opioid overdose.

Geneva: World Health Organization; 2014.
Comment: WHO endorses lay naloxone.

Al-Abri SA, Woodburn C, Olson KR, Kearney TE.
Am J Cardiovasc Drugs. 2015 Feb;15(1):43-50. doi: 10.1007/s40256-014-0104-1.
Comment: Stimulants, antidepressants, etc.

Bagley SM, Peterson J, Cheng DM, Jose C, Quinn E, O'Connor PG, Walley AY.
Subst Abus. 2015 Jan 7:0. [Epub ahead of print]
Comment: Makes sense.

Hendrikson H, Hansen M.
NCSL Legisbrief. 2014 Dec;22(45):1-2.
Comment: More on methadone as being of high risk when used for pain management.

Johnson B, Richert T.
J Psychoactive Drugs. 2014 Nov-Dec;46(5):427-35. doi: 10.1080/02791072.2014.960109.
Comment: “Patients who share their medication with opioid-dependent friends are seen as less culpable than those who sell to anyone for money.”

Gambaro V, Argo A, Cippitelli M, Dell'Acqua L, Farè F, Froldi R, Guerrini K, Roda G, Rusconi C, Procaccianti P.
J Anal Toxicol. 2014 Jun;38(5):289-94. doi: 10.1093/jat/bku016. Epub 2014 Apr 11.
Comment: Establishing overdose as caused by heroin can be tricky these days and work like this is important.

Maurer U, Kager C, Fellinger C, Loader D, Pollesböck A, Spitzer B, Jarisch R.
Subst Abuse Treat Prev Policy. 2014 Feb 27;9:12. doi: 10.1186/1747-597X-9-12.
Comment: Heroin injectors have high baseline rates of histamine, suggesting that they be at higher risk than others for allergic reactions to substances.

Stogner JM.
Ann Emerg Med. 2014 Dec;64(6):637-9. doi: 10.1016/j.annemergmed.2014.07.017. Epub 2014 Aug 18. No abstract available.
Comment: Acetyl fentanyl is a major problem in the eastern half of the U.S. these days.

Petrushevska T, Jakovski Z, Poposka V, Stefanovska VV.
J Forensic Leg Med. 2015 Apr;31:12-8. doi: 10.1016/j.jflm.2014.12.013. Epub 2015 Jan 7.
Comment: Survey of drug-related deaths in Macedonia.

Yen YF, Chou P, Lin YS, Deng CY.
J Chin Med Assoc. 2015 Feb 26. pii: S1726-4901(15)00005-2. doi: 10.1016/j.jcma.2015.01.001. [Epub ahead of print]
Comment: History of overdose was associated with a poor quality of life.

Lee JD, McDonald R, Grossman E, McNeely J, Laska E, Rotrosen J, Gourevitch MN.
Addiction. 2015 Feb 23. doi: 10.1111/add.12894. [Epub ahead of print]
Comment: Compared to nothing, there was less relapse in the first 4 weeks out of jail with injected naltrexone, which blocks opioid receptors for 4 weeks.

Pap Á, Hegedűs K.
Orv Hetil. 2015 Mar 1;156(9):352-7. doi: 10.1556/OH.2015.30091. Hungarian.
Comment: Comments on overdose and naloxone from Hungary.

Strang J, Bird SM, Dietze P, Gerra G, McLellan AT.
BMJ. 2014 Nov 4;349:g6580. doi: 10.1136/bmj.g6580. No abstract available.
Comment: Authors state their belief that waiting for data should not delay implementation of naloxone programs.

Doyon S, Aks SE, Schaeffer S; American Academy of Clinical Toxicology; American College of Medical Toxicology; American Association of Poison Control Centers.
Clin Toxicol (Phila). 2014 Dec;52(10):989-92. doi: 10.3109/15563650.2014.968657. Epub 2014 Oct 6. No abstract available.
Comment: Thanks to Corey Davis for sending, this is a position statement strongly in support of naloxone availability.

Lovegrove MC, Mathew J, Hampp C, Governale L, Wysowski DK, Budnitz DS.
Pediatrics. 2014 Oct;134(4):e1009-16. doi: 10.1542/peds.2014-0840. Epub 2014 Sep 15.
Comment: Buprenorphine was associated with quite a number of accidental pediatric ingestions.

Hammett TM, Phan S, Gaggin J, Case P, Zaller N, Lutnick A, Kral AH, Fedorova EV, Heimer R, Small W, Pollini R, Beletsky L, Latkin C, Des Jarlais DC.
BMC Health Serv Res. 2014 Jun 17;14:261. doi: 10.1186/1472-6963-14-261.
Comment: There are lots of barriers to pharmacists serving in this role.

Karch SB.
J Addict Med. 2014 May-Jun;8(3):217-9. doi: 10.1097/ADM.0000000000000036. No abstract available.
Comment: Unable to access. Racemic methadone may be associated with cardiac arrhythmias like torsades de pointes.



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